7 Best Anti Nausea Meds for Dogs That Truly Work

Watching your dog drool, lick their lips, and look miserable is upsetting.
You may hear their stomach gurgle. You may see them gag or throw up.

In those moments, many pet parents start searching for anti nausea meds for dogs.
You just want something safe that truly works and helps your dog feel normal again.

This guide walks you through seven of the most commonly used nausea medications for dogs.
Some are prescription-only. Others are over‑the‑counter but still need veterinary guidance.

You will learn:

• How each medication works
• When vets usually recommend it
• Possible side effects
• Safety tips and real‑life examples

This article is for education only. It does not replace a veterinarian’s exam.
Never start or stop medications without your vet’s advice.

Understanding Nausea in Dogs: Signs, Causes, and When to Worry 🤢

Dogs cannot say “I feel sick,” so we must watch for clues.

Common signs of nausea in dogs include:

• Excessive drooling
• Licking lips or air
• Swallowing repeatedly
• Hunched posture or restlessness
• Turning away from food
• Eating grass
• Gulping or burping
• Vomiting or dry heaving

Some causes are simple. Others can be very serious.

Frequent causes of nausea and vomiting in dogs:

• Dietary indiscretion (trash, table scraps, sudden food change)
• Motion sickness in the car
• Stomach irritation or gastritis
• Pancreatitis
• Intestinal parasites
• Foreign body (toy, sock, bone pieces)
• Kidney or liver disease
• Certain medications or toxins

According to the American Kennel Club (https://www.akc.org/expert-advice/health/dog-vomiting/), vomiting can be mild and self‑limited or a sign of an emergency.

See your vet urgently if your dog:

• Vomits repeatedly
• Has blood in vomit or stool
• Seems very weak or collapses
• Has a swollen or painful abdomen
• Cannot keep water down

Nausea medicine for dogs works best when the underlying cause is identified.
Your vet may recommend blood work, X‑rays, or ultrasound before prescribing treatment.

The 7 Best Anti Nausea Meds for Dogs That Truly Work

Below are seven veterinary‑trusted options.
Some are “gold standard” prescription drugs.
Others are supportive medications that often help with nausea and stomach upset.

Always ask your veterinarian which option fits your dog’s age, weight, and health.

1. Cerenia (maropitant): The Gold Standard Prescription Antiemetic

Cerenia is one of the most commonly prescribed anti nausea meds for dogs.
Its generic name is maropitant.

How it works:

• Blocks a specific receptor (NK‑1) in the vomiting center of the brain
• Helps stop both nausea and vomiting
• Works for motion sickness and for many other causes

Key benefits:

• Often starts working within one to two hours
• Can be given as a tablet or injection
• Safe for many dogs when used as directed
• Can be used short term or longer term in some cases

Typical uses:

• Acute vomiting from gastroenteritis
• Pancreatitis, kidney disease, or liver disease support
• Nausea from chemotherapy
• Motion sickness during travel

Possible side effects:

• Mild lethargy
• Decreased appetite
• Rarely diarrhea or drooling

Your vet will decide whether an injection or tablets work best.
In very sick dogs, an injection is often used first.

Real‑life example:
Bella, a 5‑year‑old Lab, vomited three times after eating something outside.
Her vet gave a Cerenia injection and she stopped vomiting that day. 🐕

2. Ondansetron: A Human Antiemetic Used Safely in Dogs

Ondansetron is a well‑known human nausea medication that veterinarians also use.
It works by blocking serotonin receptors in the gut and brain.

How it helps dogs:

• Reduces nausea related to chemotherapy
• Helps with certain gastrointestinal causes
• Can be very helpful when Cerenia alone is not enough

It comes in tablet, liquid, and injectable forms.
Only your vet should choose the right formulation and dose.

Typical uses:

• Cancer patients during chemotherapy
• Dogs with severe or chronic nausea
• Certain cases of pancreatitis or toxin exposure

Common side effects:

• Mild constipation or diarrhea
• Possible sleepiness
• Changes in heart rhythm in rare cases

This medication is prescription only.
Never give human ondansetron from your own medicine cabinet without veterinary guidance.

Real‑life example:
Max, a senior Golden Retriever with cancer, refused food after chemo.
With ondansetron added to his plan, he felt well enough to eat again. 💛

3. Metoclopramide (Reglan): Nausea Relief and Gut Motility Support

Metoclopramide is another prescription medication often used for vomiting dogs.
It works in two main ways.

First, it acts on the brain to reduce the vomiting reflex.
Second, it increases movement in the upper digestive tract.

Because of that, it is especially helpful when:

• Food is sitting in the stomach too long
• There is reflux from the stomach into the esophagus
• The dog has certain post‑surgery gut slowdowns

Typical uses:

• Dogs with delayed stomach emptying
• Nausea due to reflux or mild gastritis
• Supportive care after some surgeries

Common side effects:

• Restlessness or agitation in some dogs
• Changes in behavior or whining
• Rarely, muscle tremors or disorientation

If you notice unusual behavior, contact your vet immediately.

This nausea medicine for dogs is usually given several times daily.
Your vet will set the schedule based on your dog’s needs.

Real‑life example:
Luna, a small mixed breed, vomited undigested food hours after meals.
With metoclopramide and a special diet, her symptoms improved. 🌙

4. Meclizine: Motion Sickness Relief for Car‑Sick Pups 🚗

Meclizine is an antihistamine often used for motion sickness in both humans and dogs.
Many vets recommend it for dogs that get queasy in the car.

How it works:

• Acts on the inner ear and brain centers that control balance
• Reduces vertigo, dizziness, and motion‑triggered nausea

Typical uses:

• Dogs that drool, pant, or vomit in the car
• Dogs anxious about travel due to previous sickness

Benefits:

• Often given once daily
• Can make road trips much easier for sensitive dogs
• May cause mild sedation that helps anxious travelers

Common side effects:

• Drowsiness
• Dry mouth or mild urinary retention
• In rare cases, paradoxical excitement

Meclizine is sometimes available over the counter for humans.
However, you should never guess your dog’s dose.
Your veterinarian must determine if it is safe and at what strength.

Real‑life example:
Charlie used to vomit on every car ride.
With meclizine and slower trips, he now rides calmly to the park. 🌳

5. Dimenhydrinate (Dramamine): Another Option for Travel Nausea

Dimenhydrinate, known by the brand name Dramamine, is another motion sickness drug.
It is also an antihistamine with anti‑vomiting effects.

Vets sometimes prefer one travel nausea medication over another.
It depends on the dog’s health, lifestyle, and response.

How it helps:

• Reduces nausea from car, boat, or plane travel
• Can be part of a plan with training to reduce travel fear

Potential side effects:

• Sleepiness
• Dry mouth
• Decreased coordination in some dogs

Again, dosage for dogs is not the same as for humans.
Never give Dramamine without checking with your veterinarian first.

Helpful tips when using motion sickness meds:

• Start several hours before travel, as your vet advises
• Avoid feeding a large meal right before the trip
• Use a secure crate or harness to reduce anxiety and movement

Real‑life example:
Sasha’s family loves weekend trips.
With vet‑approved dimenhydrinate and crate training, Sasha travels comfortably now. 🐾

6. Famotidine (Pepcid): Stomach Acid Control for Nausea

Famotidine, often known as Pepcid, is a stomach acid reducer.
It is not a direct antiemetic like Cerenia.
However, many vets use it as part of a nausea treatment plan.

How it works:

• Decreases acid production in the stomach
• Helps soothe irritated stomach lining
• Can reduce discomfort that leads to nausea

Typical uses:

• Mild gastritis or stomach upset
• Dogs on medications that may irritate the stomach
• Some cases of reflux or heartburn‑like signs

Common side effects:

• Usually well tolerated
• Rarely, diarrhea or changes in appetite

Although it is sold over the counter for humans, dosing dogs is different.
Dogs with kidney disease, liver disease, or other problems need extra caution.

Your vet may recommend famotidine together with stronger anti nausea meds for dogs.
This combination can reduce both vomiting and stomach discomfort.

Real‑life example:
Toby occasionally vomited yellow bile early in the morning.
With adjusted feeding times and short courses of famotidine, his episodes decreased. 🌅

7. Omeprazole and Related Acid‑Reducing Meds

Omeprazole is a proton pump inhibitor.
It strongly reduces stomach acid production.

Like famotidine, it is not a classic nausea drug.
Still, it can greatly help dogs whose nausea stems from acid irritation.

Typical uses:

• Suspected ulcers or severe gastritis
• Dogs on long‑term medications that may hurt the stomach
• Some cases of reflux or chronic vomiting

Omeprazole is more potent and longer lasting than famotidine.
Your vet chooses between them based on exam findings and tests.

Possible side effects:

• Soft stools or diarrhea
• Gas or mild bloating
• Changes in appetite

Long‑term use should always be supervised by a veterinarian.
Reducing stomach acid too much can have side effects over time.

Real‑life example:
Rex had chronic vomiting and black, tarry stools.
With ulcer treatment that included omeprazole, his energy and appetite returned. 🐕‍🦺

Comparison Table: Common Nausea Medications for Dogs

Medication	Prescription or OTC	Primary Use	Main Benefits	Common Side Effects
Cerenia (maropitant)	Prescription	General nausea, vomiting, motion sickness	Fast, effective, works for many causes	Mild lethargy, decreased appetite
Ondansetron	Prescription	Chemotherapy and severe nausea	Helpful when other meds are not enough	Constipation, diarrhea, rare heart effects
Metoclopramide	Prescription	Nausea with poor stomach emptying	Reduces vomiting, improves gut motility	Restlessness, behavior changes
Meclizine	Vet‑directed, sometimes OTC human	Motion sickness	Helps car‑sick dogs, simple dosing	Drowsiness, dry mouth
Dimenhydrinate (Dramamine)	Vet‑directed, sometimes OTC human	Travel‑related nausea	Useful for cars, boats, planes	Sedation, decreased coordination
Famotidine (Pepcid)	Vet‑directed, often OTC human	Acid‑related stomach upset	Soothes stomach lining, supports comfort	Rare GI changes
Omeprazole	Prescription or vet‑directed	Ulcers, severe acid problems	Strong acid reduction, ulcer support	Soft stool, gas, appetite changes

Your veterinarian will recommend one or a combination of these options.
They will also guide you on diet and home care.

Other Supportive Treatments That Help With Dog Nausea

Medication is only part of the picture.
Your vet may suggest other steps to help your dog feel better.

Common supportive measures:

• Temporary bland diet (boiled chicken and rice, or prescription diet)
• Small, frequent meals instead of large ones
• Ensuring access to fresh water
• Probiotics to support gut health
• Rest and stress reduction

VCA Animal Hospitals (https://vcahospitals.com/know-your-pet/vomiting-in-dogs) emphasize the importance of addressing root causes.
For example, a dog that ate a toy needs surgery, not just anti‑nausea medicine.

Never withhold food or water for long periods without veterinary advice.
This can worsen dehydration and delay recovery.

Safety Tips Before Using Any Anti Nausea Meds for Dogs

Because dogs vary so much in size and health, safety is critical.

Follow these guidelines before giving any nausea medicine:

• Always consult your veterinarian first
• Never use human medications without explicit vet approval
• Share all current meds and supplements with your vet
• Mention any history of seizures, heart problems, or chronic disease
• Follow the exact dose, timing, and duration instructions
• Watch carefully for side effects or behavior changes

Seek urgent veterinary help if you see:

• Collapse or extreme weakness
• Pale gums or labored breathing
• Bloated, painful belly
• Ongoing vomiting despite medication
• Seizures or severe agitation

Some “natural” remedies can still be harmful.
Even herbs and essential oils may interact with medications.
Always check with your vet first.

Frequently Asked Questions About Nausea Medicine for Dogs

1. Can I give my dog human nausea medication like Zofran or Dramamine?

Sometimes, yes, but only with veterinary dosing and approval.
Zofran is the brand name for ondansetron, and Dramamine is dimenhydrinate.
Doses for humans are not safe for many dogs.
Certain human nausea drugs can be dangerous or even fatal to pets.

2. What can I give my dog for nausea at home?

Without vet guidance, focus on supportive care only.
Offer small amounts of water or ice chips.
Feed a bland diet if your vet has previously advised this for mild stomach issues.
If vomiting or nausea continues more than 12–24 hours, call your vet.
Do not start over‑the‑counter medications on your own.

3. How long do anti nausea meds for dogs take to work?

It depends on the medication and how it is given.
Cerenia injections often work within one to two hours.
Tablets may take a little longer.
Motion sickness meds usually need to be given ahead of travel.
Your vet will tell you the expected timing during your visit.

4. Are these medications safe for puppies and senior dogs?

Many are safe when used correctly, but dosing is very specific.
Puppies, seniors, and dogs with kidney or liver disease need extra caution.
Your vet may choose milder options or adjust doses.
Never give a young puppy any medication without veterinary advice.

5. Can diet changes alone fix my dog’s nausea?

Sometimes, especially with mild stomach upset.
A temporary bland diet and avoiding rich treats may help.
However, diet alone is not enough for serious problems.
Foreign bodies, pancreatitis, and organ disease require medical treatment.

6. When should I skip home care and go straight to the vet?

Head to your vet or an emergency clinic if your dog:

• Vomits repeatedly in a short time
• Cannot keep water down
• Has blood in vomit or stool
• Seems extremely tired or painful
• Has a swollen belly or trouble breathing

In these situations, home care and oral medications may be unsafe.

Conclusion: Helping Your Dog Feel Better, Safely and Compassionately 💚

Seeing your dog nauseous is stressful and emotional.
They may hide, whine, or simply look at you with sad eyes.

The right anti nausea meds for dogs can bring real relief.
Cerenia, ondansetron, metoclopramide, meclizine, dimenhydrinate, famotidine, and omeprazole all have important roles.
Each works differently and suits different causes of nausea and vomiting.

The most important step is always the same.
Work with your veterinarian to find the safest, most effective plan.

Together, you can:

• Identify the cause of your dog’s nausea
• Choose the right medication and dose
• Adjust diet and environment for comfort
• Monitor recovery and prevent future episodes

If your dog is showing signs of nausea today, call your vet’s office.
Describe the symptoms, timing, and any recent food or toxin exposure.

With prompt care, the right nausea medicine for dogs, and a bit of extra love,
most dogs bounce back and return to their happy, tail‑wagging selves. 🐾